liminfoDrug Dose Calculator
Free reference guide: Drug Dose Calculator
About Drug Dose Calculator
The Drug Dose Calculator is a comprehensive clinical pharmacology reference covering weight-based dosing, BSA-based chemotherapy dosing (Du Bois, Mosteller formulas), ideal body weight (Devine formula), creatinine clearance (Cockcroft-Gault), eGFR (CKD-EPI 2021), and Child-Pugh hepatic scoring for medication adjustment.
This reference includes specialized dosing for pediatric patients (mg/kg, Young and Clark formulas), neonates (gestational age-based), elderly (Beers Criteria), and pregnant patients (FDA categories, PLLR). IV infusion rate calculations, dopamine/heparin/insulin drip protocols, and TPN nutrition formulas are also covered.
Therapeutic drug monitoring (TDM) sections detail Vancomycin AUC/MIC-guided dosing, aminoglycoside Hartford nomogram, Phenytoin Sheiner-Tozer correction, warfarin INR management, and Carboplatin Calvert formula. Electrolyte replacement dosing for potassium, magnesium, sodium, and bicarbonate rounds out this clinical dosing toolkit.
Key Features
- Weight-based, BSA-based, and age-based drug dosing formulas with worked examples
- Cockcroft-Gault CrCl and CKD-EPI 2021 eGFR renal dose adjustment guidance
- Child-Pugh hepatic function scoring for liver-impaired patients
- Pediatric, neonatal, geriatric, and pregnancy-specific dosing protocols
- IV infusion rate calculations including drops/min and ug/kg/min conversions
- Dopamine, heparin, insulin, and vancomycin drip protocol references
- Therapeutic drug monitoring for vancomycin, aminoglycosides, phenytoin, and warfarin
- Electrolyte replacement formulas for K+, Mg2+, Na+, HCO3-, and TPN calculation
Frequently Asked Questions
What dosing formulas does this calculator reference?
It covers weight-based (mg/kg), BSA-based (mg/m2 using Du Bois and Mosteller formulas), ideal body weight (Devine formula), adjusted body weight, loading dose (LD = Cp x Vd / F), and maintenance dose (MD = Cp x CL x tau / F) calculations with step-by-step examples.
How does it calculate creatinine clearance?
The reference includes the Cockcroft-Gault formula: CrCl = (140 - age) x weight / (72 x SCr), multiplied by 0.85 for females. It also covers CKD-EPI 2021 race-free eGFR with CKD staging from G1 (>=90) through G5 (<15 mL/min).
What IV infusion protocols are included?
Infusion rate calculations for mL/h and drops/min, ug/kg/min to mL/h conversion, plus specific protocols for dopamine (1-20 ug/kg/min ranges), heparin (80 units/kg bolus + 18 units/kg/h), and insulin (DKA/HHS protocol with potassium monitoring).
How does the Vancomycin TDM section work?
It covers both traditional trough monitoring (10-20 ug/mL) and the current AUC/MIC-guided approach (target 400-600) using Bayesian software. Loading dose of 25-30 mg/kg for severe infections and renal adjustment guidelines are included.
What pediatric dosing methods are available?
Four approaches are detailed: weight-based (mg/kg/day), BSA-based (BSA/1.73 x adult dose), Young formula (age-based), and Clark formula (weight in lb-based). Neonatal dosing considers gestational age, postmenstrual age, and immature hepatic/renal function.
How is hepatic dose adjustment handled?
The Child-Pugh scoring system evaluates five parameters (encephalopathy, ascites, bilirubin, albumin, PT INR) to classify liver function as Class A (5-6), B (7-9), or C (10-15). Many medications require dose reduction or are contraindicated in Class C.
What electrolyte replacement formulas are included?
Potassium (1 mEq/L decrease = 200-400 mEq deficit), magnesium (MgSO4 1-2g IV), sodium deficit formula (0.6 x wt x delta Na), bicarbonate deficit (0.5 x wt x delta HCO3), and the 4-2-1 fluid maintenance rule (Holliday-Segar) are all covered.
Does it cover chemotherapy dose calculations?
Yes, including the Carboplatin Calvert formula (dose = AUC x (GFR + 25)), dose intensity concepts, and grade 3-4 toxicity dose reduction guidelines for neutropenia, thrombocytopenia, hepatotoxicity, and nephrotoxicity.